期刊
JOURNAL OF CLINICAL LIPIDOLOGY
卷 11, 期 6, 页码 1318-1328出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacl.2017.08.020
关键词
Small for gestational age; Lipoprotein; Cholesteryl ester transfer protein (CETP); Zebrafish; Embryo
资金
- Medical Research Center Program through National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning [2015R1A5A2009124]
- Seoul Metropolitan Government Seoul National University (SMG-SNU) Boramae Medical Center [02-2015-4]
BACKGROUND: Fetal growth restriction (GR) is associated with perinatal mortality and subsequent metabolic disorders in adulthood. Until now, there is little information regarding changes in the properties of lipoproteins from growth-restricted fetuses and their maternal sera. OBJECTIVE: To identify unique lipoprotein biomarkers for fetal GR in maternal and cord sera from small neonates, we analyzed lipoprotein compositions and functions. METHODS: Lipoprotein compositions and functions were compared between cord blood and maternal blood among small for gestational age neonates (SGA; n = 15, 2589 +/- 50 g) and appropriate for gestational age neonates (AGA; n = 15) in Korea. RESULTS: Cord blood from the SGA group showed 2-fold higher triglyceride (TG) and TG/high-density lipoprotein cholesterol levels than the AGA group as well as significantly lower (up to 20%) paraoxonase activity and apolipoprotein (apo) A-I content. The SGA group showed the highest cholesteryl ester transfer protein activities in both cord and maternal sera. SGA neonates showed elevated apo-B content in very low-density lipoprotein, 52% reduction of apo A-I content in high-density lipoprotein, and 30% increased glycation (P < .001) compared with AGA neonates. Especially, low-density lipoprotein from the SGA group showed 1.9-fold higher sensitivity to oxidation as well as 3-fold greater uptake into macrophages, suggesting stronger proatherosclerotic properties. Lipoproteins from maternal serum of SGA neonates showed greater oxidation along with TG enrichment and loss of antioxidant ability. On microinjection of cord serum (50 nL) into zebrafish embryos, the SGA group showed the most severe embryonic damage. CONCLUSIONS: Lipoproteins from cord and maternal sera of SGA neonates resulted in severe impairment of functional and structural correlations accompanied by greater pro-oxidant and proatherosclerotic properties. (C) 2017 National Lipid Association. All rights reserved.
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