期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 127, 期 1, 页码 33-42出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI88879
关键词
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资金
- Canadian Institutes of Health Research (CIHR) [FDN-148385]
- Canadian Diabetes Association (CDA) [OG-3-15-5014]
- J.P. Bickell Foundation
- Ontario Ministry of Innovation Early Researcher Award
- CIHR Foundation Grant [FDN-143204]
- CDA Operating Grant [OG-3-15-4901-TL]
- Canada Foundation for Innovation
- Canada Research Chair in Immunometabolism
- CIHR
- CDA
- John Kitson McIvor Endowed Chair in Diabetes Research
- Canada Research Chair in Obesity at the Toronto General Hospital Research Institute
- University of Toronto
Obesity and diabetes are associated with increased chronic low-grade inflammation and elevated plasma glucose levels. Although inflammation in the fat and liver are established features of obesity-associated insulin resistance, the intestine is emerging as a new site for immunologic changes that affect whole-body metabolism. Specifically, microbial and dietary factors incurred by diet-induced obesity influence underlying innate and adaptive responses of the intestinal immune system. These responses affect the maintenance of the intestinal barrier, systemic inflammation, and glucose metabolism. In this Review we propose that an understanding of the changes to the intestinal immune system, and how these changes influence systemic immunity and glucose metabolism in a whole-body integrative and a neuronal-dependent network, will unveil novel intestinal pathologic and therapeutic targets for diabetes and obesity.
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