期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 127, 期 11, 页码 4148-4162出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI83626
关键词
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资金
- EU-FP7 REPROBESITY [HEALTH-F2-2008-223713]
- PAINCAGE [HEALTH-603191]
- Cariplo Foundation [2013-0786, 2016-1006]
- DIABAT [HEALTH-F2-2011-278373]
- German Research Council DFG [FOR926, CRC1080]
- European Foundation for the Study of Diabetes
- INSERM
- Region Aquitaine
- Agence Nationale de la Recherche [OPTOPATH ANR-10-EQPX-08, ANR-10-LABX-0043, ANR-13-BSV4-0006]
- PhD Fellowship INSERM/Region Aquitaine
- European Research Council (ENDOFOOD) [ERC-2010-StG-260515, ERC-2014-PoC-640923]
- Fondation pour la Recherche Medicale [DRM20101220445, DPP20151033974]
- Human Frontiers Science Program (HFSP)
- Ministero dell'Istruzione, dell'Universita e della Ricerca [2009E48P9M, 2010329EKE-004]
- Labex Brain [ANR-10-LABX-43]
- German Research Foundation DFG [INST 247/646-1 FUGG, INST 247645-1 FUGG]
- Agence Nationale de la Recherche (ANR) [ANR-13-BSV4-0006] Funding Source: Agence Nationale de la Recherche (ANR)
Dysregulated adipocyte physiology leads to imbalanced energy storage, obesity, and associated diseases, imposing a costly burden on current health care. Cannabinoid receptor type-1 (CB1) plays a crucial role in controlling energy metabolism through central and peripheral mechanisms. In this work, adipocyte-specific inducible deletion of the CB1 gene (Ati-CB1-KO) was sufficient to protect adult mice from diet-induced obesity and associated metabolic alterations and to reverse the phenotype in already obese mice. Compared with controls, Ati-CB1-KO mice showed decreased body weight, reduced total adiposity, improved insulin sensitivity, enhanced energy expenditure, and fat depot-specific cellular remodeling toward lowered energy storage capacity and browning of white adipocytes. These changes were associated with an increase in alternatively activated macrophages concomitant with enhanced sympathetic tone in adipose tissue. Remarkably, these alterations preceded the appearance of differences in body weight, highlighting the causal relation between the loss of CB1 and the triggering of metabolic reprogramming in adipose tissues. Finally, the lean phenotype of Ati-CB1-KO mice and the increase in alternatively activated macrophages in adipose tissue were also present at thermoneutral conditions. Our data provide compelling evidence for a crosstalk among adipocytes, immune cells, and the sympathetic nervous system (SNS), wherein CB1 plays a key regulatory role.
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