期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 102, 期 8, 页码 2814-2824出版社
OXFORD UNIV PRESS INC
DOI: 10.1210/jc.2016-3963
关键词
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资金
- National Institutes of Health (NIH) [K23 MH092560, T32 DK007028]
- Harvard Catalyst Grant [UL1 RR025758]
Context: Oxytocin (OXT), an anorexigenic hypothalamic hormone anabolic to bone, may reflect energy availability. Basal serum OXT levels are lower in anorexia nervosa (AN, state of energy deficit) than healthy controls (HC) and negatively associated with spine bone mineral density (BMD). Reports are conflicting regarding OXT levels in overweight/obesity (OB, state of energy excess). Relationships between OXT and BMD in OB and hip geometry across the weight spectrum are unknown. Objective: To determine whether overnight serum OXT levels are (1) elevated in OB and (2) associated with body composition, BMD, and hip geometry across the weight spectrum. Design: Cross-sectional. Setting: Clinical research center. Participants: Fifty-nine women, ages 18 to 45 years: amenorrheic AN (N = 16), eumenorrheic HC (N = 24), eumenorrheic OB (N = 19). Main Outcome Measures: Serum sampled every 20 minutes from 8 PM to 8 AM and pooled for integrated overnight OXT levels. Body composition, BMD, and hip structural analysis measured by dual x-ray absorptiometry. Results: OXT levels were lowest in AN, higher in HC, and highest in OB (P <= 0.02). There were positive associations between OXT and (1) body mass index (P = 0.0004); (2) total, visceral, and subcutaneous fat (P <= 0.0002); (3) spine and hip BMD Z-scores (P <= 0.01); and (4) favorable hip geometry, namely buckling ratio (P <= 0.05). In a subset analysis of HC and OB, relationships between OXT and body composition, but not bone parameters, remained significant. Conclusions: These data suggest OXT is a marker of energy availability and may be a mediator of bone density, structure, and strength. OXT pathways may provide targets for obesity and osteoporosis treatment.
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