期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 102, 期 6, 页码 1898-1907出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2016-2785
关键词
-
资金
- Portuguese Foundation for Science and Technology [SFRH/BD/111321/2015, SFRH/BD/81940/2011]
- Fundo Europeu de Desenvolvimento Regional funds through the COMPETE Operational Programme for Competitiveness and Internationalization, Portugal
- Fundacao Para a Ciencia e a Tecnologia/Ministerio da Ciencia, Tecnologia, e Inovacao in the framework of the Institute for Research and Innovation in Health Sciences Project [POCI-01-0145-FEDER-007274]
- Advancing Cancer Research: From Basic Knowledge to Application Project [NORTE-01-0145-FEDER-000029]
- Projetos Estruturados de I&D&I, Norte-Programa Operacional Regional do Norte
- Instituto de Salud Carlos III, Ministry of Economy and Competitiveness, Madrid, Spain [PI15/01501-FEDER]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/81940/2011, SFRH/BD/111321/2015] Funding Source: FCT
Context: Little is known about the frequency of key mutations in thyroid cancer metastases and its relationship with the primary tumor genotype. Objectives: To evaluate the frequency of TERT promoter (TERTp), BRAF, and NRAS mutations in metastatic thyroid carcinomas, analyzing primary thyroid tumors, lymphnode metastases (LNMs), and distant metastases. Design and Patients: Mutation analysis was performed in 437 tissue samples from 204 patients, mainly with papillary thyroid carcinomas (PTCs; n = 180), including 196 LNMs and 56 distant metastases. All the distant metastases included corresponded to radioiodine-refractory metastatic tissue. Results: We found the following mutation frequency in primary PTCs, LNMs, and distant metastases, respectively: TERTp: 12.9%, 10.5%, and 52.4%; BRAF: 44.6%, 41.7%, and 23.8%; and NRAS: 1.2%, 1.3%, and 14.3%. There was a significant concordance between the primary tumor genotype and the corresponding LNM for all the genes, in particular BRAF-mutated PTC. The overall concordance between primary tumors and respective distant metastases was low. In the group of patients with PTCs, we found a high frequency of TERTp mutations and a low frequency of BRAF mutations in distant metastases, in comparison with the paired primary tumors. When present in distant metastases, BRAF mutations frequently coexisted with TERTp mutations. Conclusions: When the genotype of primary tumors is compared with the genotype of LNMs, the concordance is high for all the genes studied. On the other hand, distant metastases show an enrichment in TERTp mutations and a decrease in BRAF mutations. TERTp mutations may play a role in distant metastases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据