期刊
ADVANCED BIOSYSTEMS
卷 4, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adbi.201900239
关键词
conjugative; CR-HvKP; hypervirulence plasmid; Klebsiella pneumoniae; transmission
资金
- Collaborative Research Fund from the Research Grant Council of the Government of Hong Kong SAR [C5026-16G]
- Research Impact Fund [R5011-18F]
The rapid dissemination of non-conjugative virulence plasmids among non-K1/K2 types of Klebsiella pneumoniae poses an unprecedented threat to human health, yet the underlying mechanisms governing dissemination of such plasmids is unclear. In this study, a novel 68 581 bp IncFIA plasmid is discovered that can be fused to a hypervirulence-encoding plasmid to form a hybrid conjugative virulence plasmid in conjugation experiments; such fusion events involve homologous recombination between a 241 bp homologous region located in each of the two plasmids. The fusion hypervirulence-encoding plasmid can be conjugated to both classic and bla(KPC-2)-bearing carbapenem-resistant K. pneumoniae strains through conjugation, enabling such strains to acquire the ability to express the hypervirulence phenotype. Dissemination of this fusion virulence plasmid will impose an enormous burden on current efforts to control and treat infections caused by multidrug resistant and hypervirulent K. pneumoniae.
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