4.6 Article

Visible-light-promoted radical cross-coupling of para-quinone methides with N-substituted anilines: an efficient approach to 2,2-diarylethylamines

期刊

ORGANIC & BIOMOLECULAR CHEMISTRY
卷 18, 期 5, 页码 860-864

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob02600b

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资金

  1. National Natural Science Foundation of China [81972824, 21502240]
  2. Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery [2019B030301005]
  3. National Engineering and Technology Research Center for New drug Druggability Evaluation [2017B090903004]
  4. Science and Technology Program of Guangzhou [201607010118]

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An efficient protocol to access 2,2-diarylethylamines via visible-light-promoted radical reactions of para-quinone methides (p-QMs) with N-alkyl anilines has been disclosed. These reactions feature metal-free, redox-neutral, and mild reaction conditions with wide functional group compatibility.

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