期刊
CHEMICAL COMMUNICATIONS
卷 56, 期 11, 页码 1625-1628出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc09233a
关键词
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资金
- NNSFC [21877013, 21671043, 51872263]
- Zhejiang Provincial Natural Science Foundation of China [LZ19E020001, LQ19B050003]
Detection of Ab protofibrils at the early stage of Alzheimer's disease was realized by a novel near-infrared probe (DCM-AN) based on dicyanomethylene-4H-pyran. This probe exhibits high affinity towards Ab protofibrils in vitro and in brain sections of transgenic mouse models for Alzheimer's disease.
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