期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 16, 期 6, 页码 921-934出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.42300
关键词
aldehyde dehydrogenase; gene polymorphism; liver disease; hepatocellular carcinoma
资金
- National Natural Science Foundation of China [81972265]
- National key research plan precision medicine research key project [2017YFC0908103]
- National Science and Technology Major Project [2017ZX10202202, 2018ZX10302206]
- JLU Norman Bethune research plan [2018B32]
- Fundamental Research Funds for the Central Universities
- Program for JLU Science and Technology Innovative Research Team [2017TD-08]
Acetaldehyde dehydrogenase 2 (ALDH2) is the key enzyme responsible for metabolism of the alcohol metabolite acetaldehyde in the liver. In addition to conversion of the acetaldehyde molecule, ALDH is also involved in other cellular functions. Recently, many studies have investigated the involvement of ALDH expression in viral hepatitis, alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), liver fibrosis, and liver cancer. Notably, ALDH2 expression has been linked with liver cancer risk, as well as pathogenesis and prognosis, and has emerged as a promising therapeutic target. Of note, approximately 8% of the world's population, and approximately 30-40% of the population in East Asia carry an inactive ALDH2 gene. This review summarizes new progress in understanding tissue-specific acetaldehyde metabolism by ALDH2 as well as the association of ALDH2 gene polymorphisms with liver disease and cancer. New research directions emerging in the field are also briefly discussed.
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