期刊
JOURNAL OF CLEANER PRODUCTION
卷 168, 期 -, 页码 39-50出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jclepro.2017.08.235
关键词
Nanostructures; Drug delivery; XTT; Atenolol; HydroxyApatite; Magnetic materials
资金
- University of Kashan [159271/855990]
- council of Iran National Science Foundation (INSF) [159271/855990]
In the present study, magnetically Fe3O4/SiO2/hydroxyapatite (Fe3O4/SiO2/HAp) nanocomposites were synthesized and modified with 3-aminopropyl triethoxysilane (APTES) using fructose as a green capping agent. The effect of different capping agent (such as fructose and glucose) and calcination temperature were investigated to reach optimum condition. The as-prepared nanocomposites were characterized by XRD, FT-IR, SEM, EDS, TEM, DLS, VSM and N-2 adsorption-desorption isotherm technique. The as-prepared nanocomposites have been used as atenolol controlled carrier due to their advantage such as high pore size (13.37 nm) and large surface area (55.88 m(2) g(-1)). The drug release was studied in the gastrointestinal tract (intestine and stomach) pH-similar milieu. The results show that 100% and 15.6% of impregnated atenolol could be released from Fe3O4/SiO2/HAp functionalized with APTES after 30 h at pH = 6.8 and pH 1.2, respectively. Also, the histopathological experiment shows that abnormality of the liver, spleen and kidney was observed after 48 h study. (C) 2017 Elsevier Ltd. All rights reserved.
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