4.1 Article

Fluctuations in Antibody Titers against Enterovirus D68 in Pediatric Sera Collected in a Community before, during, and after a Possible Outbreak

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JAPANESE JOURNAL OF INFECTIOUS DISEASES
卷 73, 期 1, 页码 55-57

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NATL INST INFECTIOUS DISEASES
DOI: 10.7883/yoken.JJID.2019.056

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资金

  1. Clinical Research Division of Sendai Medical Center
  2. Research Program on Promoting Development of Innovative Drugs against Emerging and Reemerging Infectious Diseases at Japan Agency for Medical Research and Development (AMED)
  3. Japanese Initiative for Global of Research Network on Infections Diseases (J-GRID) at AMED
  4. Japan Society for Promotion of Scieuce (JSPS) KAKENHI
  5. Miuistry of Health, Labour and Welfare

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We previously reported a hospital-based epidemiological study on enterovirus (EV)-D68 infection among children during the autumn of 2015, which indirectly inferred an outbreak in Sendai, Japan. In this study, stocked sera of children (aged 0-6 years; without symptoms of infectious diseases) in the Sendai community collected during 4 periods (1 year before, 6 months before, immediately after, and 1 year after the possible outbreak period) were analyzed using the neutralization antibody titer assay to determine community children's immunity levels against EV-D68 infection. The immunity levels were confirmed to have increased during the possible outbreak period and to have gradually waned over 1 year without another outbreak. These results provide background information supporting the results of our previous hospital-based surveillance study.

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