Molecular targets and novel therapeutic avenues in soft-tissue sarcoma

Soft-tissue sarcoma (STS) represents a heterogeneous group of rare tumours, and a significant number of affected patients will develop metastatic disease. Outcomes in the population with metastatic disease are generally poor, especially after progression on standard chemotherapy. The advent of personalized medicine has permitted oncologists to offer targeted treatment, thus addressing the limited treatment options and poor prognosis after progression on first-line chemotherapy. In this review, we delineate the existing data and therapeutic successes with respect to existing and emerging molecular targets in STS and options for immunotherapy in STS. Our review also summarizes emerging clinical trials that are currently recruiting patients.