期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1486, 期 -, 页码 35-41出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2017.01.040
关键词
Quantitative analysis; MALDI-MS Small molecules; Recommendations; Ordinary conditions; Sample spotting
资金
- NIH Grant from NIEHS [P42WS017198]
- NIFA [2015-67030-23755]
Matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) has been used for quantitative analysis of small molecules for many years. It is usually preceded by an LC separation step when complex samples are tested. With the development several years ago of modern MALDI (automation, high repetition laser, high resolution peaks), the ease of use and performance of MALDI as a quantitative technique greatly increased. This review focuses on practical aspects of modern MALDI for quantitation of small molecules conducted in an ordinary way (no special reagents, devices or techniques for the spotting step of MALDI), and includes our ordinary, preferred methods The review is organized as 18 recommendations with accompanying explanations, criticisms and exceptions. (C) 2017 Elsevier B.V. All rights reserved.
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