期刊
MATERIALS HORIZONS
卷 7, 期 2, 页码 605-614出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9mh01255a
关键词
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资金
- Excellent Young Scientists Fund by the National Natural Science Foundation of China [31822020]
- National Natural Science Foundation of China [31771030, 31870965]
It is a tough task in the clinic to remove and refresh dressings. Inspired by the chemical structure of mussel adhesive proteins (MAP), an injectable dopamine (DOPA)-based adhesive hydrogel was constructed as a wound-healing dressing that could be easily replaced by spraying zinc ions. A hyperbranched polymer named HB-PBAE was synthesized by a Michael addition reaction between dopamine (DOPA), poly(ethylene glycol) diacrylate (PEGDA700), and pentaerythritol triacrylate (PETA). The DOPA-based adhesive hydrogel was fabricated by mixing HB-PBAE, poly(1-vinylimidazole) (PVI) and gelatin solution, followed by adding Fe3+. Intriguingly, spraying Zn2+ solution resulted in rapidly reduced adhesive strength and sharply increased strength. Importantly, the adhesive dressing reduced damage during changing the dressing in a rat wound bed and accelerated the wound-healing process. This metal ion-facilitated dressing change might provide a novel concept in the design of wound dressings.
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