期刊
CHINESE HERBAL MEDICINES
卷 12, 期 1, 页码 79-87出版社
ELSEVIER SINGAPORE PTE LTD
DOI: 10.1016/j.chmed.2019.06.003
关键词
borneol; comparative pharmacokinetics; multi-bioactive components; UHPLC-MS/MS; Xintiantai I
资金
- National Natural Science Foundation of China [81603669]
- Guangdong Science and Technology Department Public Welfare Research Project [2015B020211001]
- Natural Science Foundation of Guangdong Province [2017A030313747, 2018A030313995]
- Science and Technology Project of Shenzhen [JCYJ20160428105555220, JCYJ20180227175929767]
- Shenzhen Health and Family Planning System Research Project [201601052]
Objective: To investigate the in vivo pharmacokinetic characteristics of 17 bioactive components including ginsenoside Rgl, Rbl, Rd, berberine, epiberberine, jatrorrhizine, palmatine, columbamine, coptisine, evodiamine, dehydroevodiamine, rutaecarpine, limonin, hyperin, curcumin, demethoxycurcumin and bisdemethoxycurcumin in rat plasma after oral administration of Xintiantai I extract powder (XI) and Xintiantai I without guide drug borneol extract powder (XI without borneol), and study the compatibility effects of guide drug borneol on the pharmacokinetics. Methods: A UHPLC-MS/MS method was established and fully validated for the comparative pharmacokinetics of 17 bioactive components. The pharmacokinetics parameters of 17 bioactive components after oral administration of XI and XI without borneol were calculated by the software of DAS 3.0 and inter-compared. Results: The specificity, linearity, lower limit of quantification (LLOQ), precision, accuracy, extraction recovery rates, matrix effects, and stability of the UHPLC-MS/MS assay were good within the acceptance criteria from FDA guidelines. Guide drug borneol can significantly increase AUC of G-Rd, palmatine, hyperin, curcumin, demethoxycurcumin, bisdemethoxycurcumin and C-max of 16 bioactive components except for dehydroevodiamine (P < 0.05), decrease T-max of G-Rd, berberine, columbamin, coptisine, limonin and MRT of 17 bioactive components in XI group (P < 0.05). Conclusion: Guide drug borneol enhanced the absorption of G-Rd, palmatine, hyperin, curcumin, demethoxycurcumin and bisdemethoxycurcumin. (C) 2020 Tianjin Press of Chinese Herbal Medicines. Published by Elsevier B.V.
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