期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 37, 期 12, 页码 3643-3648出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X17732508
关键词
F-18-FDG-PET; principal component analysis; normal aging; mild cognitive impairment; Alzheimer's disease
资金
- Dutch 'Stichting ParkinsonFonds'
We investigated the expression of the Alzheimer's disease-related metabolic brain pattern (ADRP) in F-18-FDG-PET scans of 44 controls, 27 patients with mild cognitive impairment (MCI) who did not convert to Alzheimer's disease (AD) after five or more years of clinical follow-up, 95 MCI patients who did develop AD dementia on clinical follow-up, and 55 patients with mild-to-moderate AD. The ADRP showed good sensitivity (84%) and specificity (86%) for MCI-converters when compared to controls, but limited specificity when compared to MCI non-converters (66%). Assessment of F-18-FDG-PET scans on a case-by-case basis using the ADRP may be useful for quantifying disease progression.
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