相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice
Emma L. Baar et al.
AGING CELL (2016)
Potential therapeutic effects of mTOR inhibition in atherosclerosis
Ammar Kurdi et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2016)
Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases
Andras Perl
NATURE REVIEWS RHEUMATOLOGY (2016)
Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts
Ying Ann Chiao et al.
AGING-US (2016)
Glutaredoxin 2a overexpression in macrophages promotes mitochondrial dysfunction but has little or no effect on atherogenesis in LDL-receptor null mice
D. A. Zamora et al.
ATHEROSCLEROSIS (2015)
mTOR inhibitors and dyslipidemia in transplant recipients: A cause for concern?
Hallvard Holdaas et al.
TRANSPLANTATION REVIEWS (2015)
Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice
Simon C. Johnson et al.
FRONTIERS IN GENETICS (2015)
Testing Efficacy of Administration of the Antiaging Drug Rapamycin in a Nonhuman Primate, the Common Marmoset
Suzette Tardif et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2015)
Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life
Kathleen E. Fischer et al.
PLOS ONE (2015)
NADPH Oxidase 4 Is Expressed in Pulmonary Artery Adventitia and Contributes to Hypertensive Vascular Remodeling
Scott A. Barman et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)
mTOR inhibition: A promising strategy for stabilization of atherosclerotic plaques
Wim Martinet et al.
ATHEROSCLEROSIS (2014)
Cardiovascular risk factors and future risk of Alzheimer's disease
Renee F. A. G. de Bruijn et al.
BMC MEDICINE (2014)
Metabolic complications with the use of mTOR inhibitors for cancer therapy
Shanthi Sivendran et al.
CANCER TREATMENT REVIEWS (2014)
Impaired compensatory beta-cell function and growth in response to high-fat diet in LDL receptor knockout mice
Ricardo B. d Oliveira et al.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2014)
Rapamycin Extends Life and Health in C57BL/6 Mice
Yiqiang Zhang et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)
Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome
Wilson C. Fok et al.
PLOS ONE (2014)
Single Rapamycin Administration Induces Prolonged Downward Shift in Defended Body Weight in Rats
Mark Hebert et al.
PLOS ONE (2014)
An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E-/- mice
Nan Peng et al.
SCIENTIFIC REPORTS (2014)
Duration of Rapamycin Treatment Has Differential Effects on Metabolism in Mice
Yimin Fang et al.
CELL METABOLISM (2013)
Knockdown of mTOR by lentivirus-mediated RNA interference suppresses atherosclerosis and stabilizes plaques via a decrease of macrophages by autophagy in apolipoprotein E-deficient mice
Xiaochuang Wang et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2013)
Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease
Ai-Ling Lin et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2013)
mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome
Simon C. Johnson et al.
SCIENCE (2013)
CHRONIC INHIBITION OF MAMMALIAN TARGET OF RAPAMYCIN BY RAPAMYCIN MODULATES COGNITIVE AND NON-COGNITIVE COMPONENTS OF BEHAVIOR THROUGHOUT LIFESPAN IN MICE
J. Halloran et al.
NEUROSCIENCE (2012)
Exercise, brain, and cognition across the life span
Michelle W. Voss et al.
JOURNAL OF APPLIED PHYSIOLOGY (2011)
POSITIVE CORRELATION BETWEEN ELEVATED PLASMA CHOLESTEROL LEVELS AND COGNITIVE IMPAIRMENTS IN LDL RECEPTOR KNOCKOUT MICE: RELEVANCE OF CORTICO-CEREBRAL MITOCHONDRIAL DYSFUNCTION AND OXIDATIVE STRESS
J. de Oliveira et al.
NEUROSCIENCE (2011)
Chronic intermittent cold stress sensitizes neuro-immune reactivity in the rat brain
Milena Girotti et al.
PSYCHONEUROENDOCRINOLOGY (2011)
Vascular Contributions to Cognitive Impairment and Dementia A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association
Philip B. Gorelick et al.
STROKE (2011)
Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue
Vanessa P. Houde et al.
DIABETES (2010)
Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-beta Levels in a Mouse Model of Alzheimer's Disease
Patricia Spilman et al.
PLOS ONE (2010)
Immune and Inflammatory Mechanisms of Atherosclerosis
Elena Galkina et al.
ANNUAL REVIEW OF IMMUNOLOGY (2009)
Low-dose oral sirolimus reduces atherogenesis, vascular inflammation and modulates plaque composition in mice lacking the LDL receptor
L. Zhao et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
Novel cerebrovascular pathology in mice fed a high cholesterol diet
Sonia Franciosi et al.
MOLECULAR NEURODEGENERATION (2009)
Cardiovascular risk factors and dementia
Howard Fillit et al.
AMERICAN JOURNAL OF GERIATRIC PHARMACOTHERAPY (2008)
Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR-/- mice despite severe hypercholesterolemia
Marc A. Mueller et al.
ATHEROSCLEROSIS (2008)
Increased locomotor activity in mice lacking the low-density lipoprotein receptor
Gregory A. Elder et al.
BEHAVIOURAL BRAIN RESEARCH (2008)
Antidepressive-like effects of rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders
C. Cleary et al.
BRAIN RESEARCH BULLETIN (2008)
Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration
Pazit Polak et al.
CELL METABOLISM (2008)
The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response
Thomas Weichhart et al.
IMMUNITY (2008)
Be smart, exercise your heart: exercise effects on brain and cognition
Charles H. Hillman et al.
NATURE REVIEWS NEUROSCIENCE (2008)
The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes
Nicholas F. Brown et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2007)
Mouse models for atherosclerosis and pharmaceutical modifiers
Susanne Zadelaar et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)
Comparison of sirolimus and everolimus in their effects on blood lipid profiles and haematological parameters in heart transplant recipients
Gero Tenderich et al.
CLINICAL TRANSPLANTATION (2007)
Increased expression of glutathione reductase in macrophages decreases atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice
Mu Qiao et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)
Smoking, diabetes, and blood cholesterol differ in their associations with subclinical atherosclerosis: The Multiethnic Study of Atherosclerosis (MESA)
AR Sharrett et al.
ATHEROSCLEROSIS (2006)
Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease
Leonel Rojo et al.
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2006)
Rapamycin attenuates atherosclerotic plaque progression in apolipoprotein E knockout mice - Inhibitory effect on monocyte chemotaxis
R Pakala et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2005)
Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease
M Kivipelto et al.
ARCHIVES OF NEUROLOGY (2005)
Serum amyloid A stimulates matrix-metalloproteinase-9 upregulation via formyl peptide receptor like-1-mediated signaling in human monocytic cells
HY Lee et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Links between the pathology of Alzheimer's disease and vascular dementia
M Sadowski et al.
NEUROCHEMICAL RESEARCH (2004)
Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus
M Mulder et al.
NEUROBIOLOGY OF DISEASE (2004)
Monogenic hypercholesterolemia: new insights in pathogenesis and treatment
DJ Rader et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
Age-related changes in cerebral blood flow and glucose metabolism in conscious rhesus monkeys
A Noda et al.
BRAIN RESEARCH (2002)
Inflammation and atherosclerosis
P Libby et al.
CIRCULATION (2002)
分享论文
