期刊
RSC ADVANCES
卷 10, 期 11, 页码 6163-6171出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra10374k
关键词
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资金
- National Natural Science Foundation of China [51373114]
- Six Talent Peaks Project in Jiangsu Province, PAPD [SWYY-038]
- Nature Science Foundation of Jiangsu, China [BK20171239, BK20191191]
- Natural Science Foundation of Suzhou City Jiangsu Province, China [SYN201849]
This work illustrates the feasibility of a microneedle based electrochemical biosensor for continuous glucose monitoring. The device consists of three silk/d-sorbitol pyramidal microneedles integrated with platinum (Pt) and silver (Ag) wires and immobilized glucose selective enzyme (glucose oxidase, GOD) during fabrication. The silk/d-sorbitol composite can provide a biocompatible environment for the enzyme molecules. The break strength can be controlled by the ratio of silk to d-sorbitol, which guarantees microneedle penetrate into skin. The enzymatic-amperometric responses and glucose concentration were linearly correlated, and cover physiological conditions. The microneedle displays high stability both in long-term monitoring and storage, even at 37 degrees C. Our results reveal that this new microneedle biosensor is a promising tool for wearable minimally invasive continuous glucose monitoring in practical applications.
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