期刊
RSC ADVANCES
卷 10, 期 11, 页码 6351-6355出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra10749e
关键词
-
资金
- National Natural Science Foundation [81620108027, 21632008, 21877118]
- Science and Technology Commission of Shanghai Municipality [17431903100, 18431907100]
In this study, we describe a method using sulfoxonium ylides as carbene precursors to achieve C6-selective acylmethylation of pyridones catalyzed by a ruthenium(ii) complex. This approach featured mild reaction conditions, moderate to excellent yields, high step economy, and had excellent functional group tolerance with good site selectivity. Besides, gram-scale preparation, synthetic utility, and mechanistic studies were conducted. It offers a direct and efficient way to synthesize pyridone derivatives.
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