期刊
BIOMATERIALS SCIENCE
卷 8, 期 4, 页码 1101-1105出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9bm01564g
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资金
- National Research Foundation of South Korea [2018R1A5A2025286, 2018M3A9H3020844, 2014M3C1A3054153, 2017R1D1A1B03028278, 2019M3A9H1103786]
- National Research Foundation of Korea [2018M3A9H3020844, 2019M3A9H1103786, 2014M3C1A3054153, 2017R1D1A1B03028278] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
For mRNA mediated cancer immunotherapy, Pam3 was incorporated as an adjuvant within lipid nanoparticles (LNPs) with OVA mRNA. The developed Pam3 incorporated LNPs showed successful expression of tumor antigens with enhanced immune stimulation. We demonstrated that the synergies of Pam3 LNPs could greatly improve the efficacy of tumor prevention by mRNA vaccines.
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