期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 233, 期 3, 页码 2502-2512出版社
WILEY
DOI: 10.1002/jcp.26126
关键词
bone resorption; Cyanidin Chloride; osteolysis; osteoclast; RANKL
资金
- National Natural Science Foundation of China (NSFC) [31171135, 81472054]
- Australian Health and Medical Research Council NHMRC [1107828, 1027932]
- Guangxi Scientific Research and Technology Development Plan Project [GKG13349003, 1598013-15]
- Guangxi Medical University Science Foundation for Youths [GXMUYSF201617]
- Innovation Program of Postgraduate Education in Guangxi [YCSZ2015112]
- Western Australia Medical & Health Research Infrastructure Fund
- Arthritis Australia
- University of Western Australia (UWA)
Over-production and activation of osteoclasts is a common feature of osteolytic conditions such as osteoporosis, tumor-associated osteolysis, and inflammatory bone erosion. Cyanidin Chloride, a subclass of anthocyanin, displays antioxidant and anti-carcinogenesis properties, but its role in osteoclastic bone resorption and osteoporosis is not well understood. In this study, we showed that Cyanidin Chloride inhibits osteoclast formation, hydroxyapatite resorption, and receptor activator of NF-kappa B ligand (RANKL)-induced osteoclast marker gene expression; including ctr, ctsk, and trap. Further investigation revealed that Cyanidin Chloride inhibits RANKL-induced NF-kappa B activation, suppresses the degradation of I kappa B-alpha and attenuates the phosphorylation of extracellular signal-regulated kinases (ERK). In addition, Cyanidin Chloride abrogated RANKL-induced calcium oscillations, the activation of nuclear factor of activated T cells calcineurin-dependent 1 (NFATc1), and the expression of c-Fos. Further, we showed that Cyanidin Chloride protects against ovariectomy-induced bone loss in vivo. Together our findings suggest that Cyanidin Chloride is capable of inhibiting osteoclast formation, hydroxyapatite resorption and RANKL-induced signal pathways in vitro and OVX-induced bone loss in vivo, and thus might have therapeutic potential for osteolytic diseases.
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