期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 232, 期 11, 页码 2931-2937出版社
WILEY
DOI: 10.1002/jcp.25798
关键词
desmoplastic reaction; pancreatic cancer; pancreatic stellate cells; stroma
资金
- Mashhad University of Medical Sciences
Desmoplasia or abundant fibrotic stroma is a typical property of most malignancies, which has a great effect on tumorigenesis, angiogenesis, and resistance to therapy. The activated stroma cells comprises several cell types including endothelial cells, nerve cells, inflammatory/macrophages cells, stellate cells, and extracellular matrix. In other word, the interactions of cancer-stroma modulate tumorigenesis, therapy resistance, and poor delivery of drugs. Therefore, targeting the tumor stroma in combination with conventional chemotherapeutic agents could provide a promising approach in the treatment of pancreatic cancer. This review summarizes the current knowledge about pancreatic stellate cells, targeting stroma compartments with particular emphasis on preclinical, and clinical trials on targeting of stroma as an option in pancreatic cancer treatment.
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