NAD+: A big player in cardiac and skeletal muscle remodeling and aging

In the past decade, NAD(+) has gained importance for its beneficial effects as antioxidant and anti-aging molecule. A paper in science by Zhang et al. (2016) has described that NAD(+) when replenished, ameliorates muscle dystrophy in mice by improving mitochondrial function. NAD(+) was also demonstrated by the authors to improve the life span of mice. Cox et al. (2002) demonstrated the cardiac effects of NAD(+) which mitigated chronic heart failure via mitochondrial redox state mechanism. Cox et al. (2002) also demonstrated that NAD(+) is provided in the drinking water, it improves cardiac relaxation in volume overload model of heart failure. Although NAD(+) has a profound anti-aging and anti-oxidant effects, its effect on humans and use as a dietary supplement needs more exploration.