期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 18, 期 7, 页码 1417-1425出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob02635e
关键词
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资金
- Independent Research Fund Denmark Technology and Production [4148-00031]
- Carlsberg Foundation [CF17-0517]
- Danish National Research Foundation
- DNRF [118]
- Aarhus University
A copper-catalyzed decarboxylative trifluoromethylation of (hetero)aromatic iodides has been developed. Importantly, this new copper-catalyzed reaction operates in the absence of any ligands and metal additives. The protocol shows good functional group tolerance and is compatible with heteroaromatic systems. The reaction proved scalable to a 15 mmol scale with increased yield. Finally, late-stage installation of the trifluoromethyl functionality afforded the N-trifluoroacetamide variant of the antidepressant agent, Prozac, demonstrating the applicability of the developed method.
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