期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 118, 期 11, 页码 3561-3568出版社
WILEY
DOI: 10.1002/jcb.26066
关键词
CYTOKINESIS; PHOSPHOINOSITIDES; ESCRT
资金
- Fondazione Italiana Ricerca Cancro (FIRC) [19421]
- Associazione Italiana Ricerca Cancro (AIRC) [161813]
- Compagnia di San Paolo and World Wide Cancer Research Association (AICR) [151324]
- Fondazione Umberto Veronesi
Cytokinetic abscission involves the fine and regulated recruitment of membrane remodeling proteins that participate in the abscission of the intracellular bridge that connects the two dividing cells. This essential process is mediated by the concomitant activity of the endosomal sorting complex required for transport (ESCRT) and the vesicular trafficking directed to the midbody. Phosphoinositides (PtdIns), produced at plasma membrane, and endosomes, act as molecular intermediates by recruiting effector proteins involved in multiple cellular processes, such as intracellular signaling, endo- and exo-cytosis, and membrane remodeling events. Emerging evidences suggest that PtdIns have an active role in recruiting key elements that control the stability and the remodeling of the cytoskeleton from the furrow ingression to the abscission, at the end of cytokinesis. Accordingly, a possible concomitant and coordinated activity between PtdIns production and ESCRT machinery assembly could also exist and recent findings are pointing the attention on poorly understood ESCRT subunits potentially able to associate with PtdIns rich membranes. Although further studies are required to link PtdIns to ESCRT machinery during abscission, this might represent a promising field of study. J. Cell. Biochem. 118: 3561-3568, 2017. (c) 2017 Wiley Periodicals, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据