期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 118, 期 11, 页码 3953-3959出版社
WILEY
DOI: 10.1002/jcb.26050
关键词
OSTEOSARCOMA; CO-EXPRESSION; MODULES; GENE EXPRESSION; FUNCTION
资金
- Scientific Programs of Shanghai Minhang District Health And Family Planning Commission [2013MW03]
- Scientific Programs of Shanghai Municipal Commission of Health And Family Planning [201440509]
Osteosarcoma is the eighth-most common form of childhood cancer, comprising about 20% of all primary bone cancers. To date, systemic co-expression analysis for this cancer is still insufficient to explain the pathogenesis of poorly understood OC. The objective of this study was to construct a gene co-expression network to predict clusters of candidate genes involved in the pathogenesis of osteosarcoma. First, we contributed co-expression modules via weighted gene co-expression network analysis (WGCNA) and investigated the functional enrichment analysis of co-expression genes in terms of GO and KEGG. In result, seven co-expression modules were identified, containing 2,228 differentially expressed genes identified from the 22 human osteosarcoma samples. Subsequently, correlation study showed that the hub-genes between pair-wise modules displayed significant differences. Lastly, functional enrichment analysis of the co-expression modules showed that the module 5 enriched in progresses of immune response, antigen processing, and presentation. In conclusion, we identified essential genes in module 5 which were associated to human osteosarcoma. The key genes in our findings might provide the framework of co-expression gene modules of human osteosarcoma. Further, the functional analysis of these associated genes provides references to understand the mechanism of Osteosarcoma. J. Cell. Biochem. 118: 3953-3959, 2017. (c) 2017 Wiley Periodicals, Inc.
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