期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 119, 期 1, 页码 150-156出版社
WILEY
DOI: 10.1002/jcb.26199
关键词
SWIPROSIN-1; RECEPTOR SIGNALING; IMMUNE CELLS ACTIVATION; PROTEIN KINASE
资金
- MEST/KOSEF [R01-2008-000-20989-0, R11-2007-007-01002-0]
- Korea Research Foundation [2008-C00265]
- National Research Foundation of Korea [R01-2008-000-20989-0, R11-2007-007-01002-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Swiprosin-1/EFhd2 is a Ca2+ binding adapter protein involved in the various cellular functions. Swiprosin-1 is significantly upregulated in a number of pathological conditions of inflammation, neurodegeneration, and cancer. Swiprosin-1 associated with actin and its expression level amplifies the production of proinflammatory mediators and modulates the activation of transcription factor during immune cells activation. This review aims at providing an overview of the expression and function of swiprosin-1/EFhd2 in various pathophysiological conditions. We also discussed the key role of swiprosin-1 in immune cell activation, cell migration, apoptosis, humoral immunity, cancer invasion and metastasis, neuronal transport, and major signaling cascades. J. Cell. Biochem. 119: 150-156, 2018. (c) 2017 Wiley Periodicals, Inc.
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