期刊
JOURNAL OF CELL SCIENCE
卷 130, 期 24, 页码 4087-4096出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.209197
关键词
EGFR; Endosomes; ER; Signaling; Rab7; Rab5
类别
资金
- Institute of Chemical Immunology, an NWO Gravitation project - Ministry of Education, Culture and Science of the government of the Netherlands
- European Research Council
When cell surface receptors engage their cognate ligands in the extracellular space, they become competent to transmit potent signals to the inside of the cell, thereby instigating growth, differentiation, motility and many other processes. In order to control these signals, activated receptors are endocytosed and thoroughly curated by the endosomal network of intracellular vesicles and proteolytic organelles. In this Review, we follow the epidermal growth factor (EGF) receptor (EGFR) from ligand engagement, through its voyage on endosomes and, ultimately, to its destruction in the lysosome. We focus on the spatial and temporal considerations underlying the molecular decisions that govern this complex journey and discuss how additional cellular organelles - particularly the ER - play active roles in the regulation of receptor lifespan. In summarizing the functions of relevant molecules on the endosomes and the ER, we cover the order of molecular events in receptor activation, trafficking and downregulation, and provide an overview of how signaling is controlled at the interface between these organelles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据