期刊
JOURNAL OF CELL SCIENCE
卷 130, 期 21, 页码 3619-3630出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.200667
关键词
Connexin 43; GJA1; Extracellular vesicles; Gap junction; Intercellular communication; Tunnelling nanotube
类别
资金
- European Regional Development Fund (ERDF) through the Operational Program for Competitiveness Factors (COMPETE) [PAC 'NETDIAMOND' POCI-01-0145-FEDER-016385, Healthy Aging 2020 CENTRO-01-0145-FEDER-000012-N2323, POCI-01-0145-FEDER-007440, FCT-UID/NEU/04539/2013, PD/BD/52294/2013, PD/BD/106043/2015]
- Fundacao para a Ciencia e a Tecnologia (FCT)
- Swiss National Science Foundation [310030_162579/1]
- SystemsX.ch [2014/261 'AneuX']
- Fundação para a Ciência e a Tecnologia [PD/BD/106043/2015] Funding Source: FCT
Communication is important to ensure the correct and efficient flow of information, which is required to sustain active social networks. A fine-tuned communication between cells is vital to maintain the homeostasis and function of multicellular or unicellular organisms in a community environment. Although there are different levels of complexity, intercellular communication, in prokaryotes to mammalians, can occur through secreted molecules (either soluble or encapsulated in vesicles), tubular structures connecting close cells or intercellular channels that link the cytoplasm of adjacent cells. In mammals, these different types of communication serve different purposes, may involve distinct factors and are mediated by extracellular vesicles, tunnelling nanotubes or gap junctions. Recent studies have shown that connexin 43 (Cx43, also known as GJA1), a transmembrane protein initially described as a gap junction protein, participates in all these forms of communication; this emphasizes the concept of adopting strategies to maximize the potential of available resources by reutilizing the same factor in different scenarios. In this Review, we provide an overview of the most recent advances regarding the role of Cx43 in intercellular communication mediated by extracellular vesicles, tunnelling nanotubes and gap junctions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据