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Herpes Simplex Virus and Interferon Signaling Induce Novel Autophagic Clusters in Sensory Neurons
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ISG15 deficiency and increased viral resistance in humans but not mice
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Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification
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NATURE COMMUNICATIONS (2016)
Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins
Chen Zhao et al.
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ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins
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ISG15 predicts poor prognosis and promotes cancer stem cell phenotype in nasopharyngeal carcinoma
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ONCOTARGET (2016)
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PLOS PATHOGENS (2016)
Extracellular vesicle-associated Aβ mediates trans-neuronal bioenergetic and Ca2+-handling deficits in Alzheimer's disease models
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NPJ AGING AND MECHANISMS OF DISEASE (2016)
Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation
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ACTA NEUROPATHOLOGICA (2015)
Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon
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USP18 lack in microglia causes destructive interferonopathy of the mouse brain
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Interferon-Stimulated Gene 15 Upregulation Precedes the Development of Blood-Brain Barrier Disruption and Cerebral Edema after Traumatic Brain Injury in Young Mice
Janet L. Rossi et al.
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Ubiquitin-like Molecule ISG15 Acts as an Immune Adjuvant to Enhance Antigen-specific CD8 T-cell Tumor Immunity
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Type I IFN induces protein ISGylation to enhance cytokine expression and augments colonic inflammation
Jun-Bao Fan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Free ISG15 triggers an antitumor immune response against breast cancer: a new perspective
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ONCOTARGET (2015)
Identification and characterization of a novel ISG15-ubiquitin mixed chain and its role in regulating protein homeostasis
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SCIENTIFIC REPORTS (2015)
ISG15 counteracts Listeria monocytogenes infection
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ELIFE (2015)
ISG15: A double edged sword in cancer
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Interferon-stimulated Gene 15 (ISG15) and ISG15-linked Proteins Can Associate with Members of the Selective Autophagic Process, Histone Deacetylase 6 (HDAC6) and SQSTM1/p62
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JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Novel Mode of ISG15-Mediated Protection against Influenza A Virus and Sendai Virus in Mice
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Human intracellular ISG15 prevents interferon-alpha/beta over-amplification and auto-inflammation
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ISG15 Is a Critical Microenvironmental Factor for Pancreatic Cancer Stem Cells
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CANCER RESEARCH (2014)
ISG15 Functions as an Interferon-Mediated Antiviral Effector Early in the Murine Norovirus Life Cycle
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JOURNAL OF VIROLOGY (2014)
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Modification of PCNA by ISG15 Plays a Crucial Role in Termination of Error-Prone Translesion DNA Synthesis
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MOLECULAR CELL (2014)
ISGylation governs the oncogenic function of Ki-Ras in breast cancer
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ONCOGENE (2014)
Interferon-stimulated gene 15 (ISG15) is a trigger for tumorigenesis and metastasis of hepatocellular carcinoma
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ONCOTARGET (2014)
Type I interferons induce autophagy in certain human cancer cell lines
Hana Schmeisser et al.
AUTOPHAGY (2013)
Type I Interferon Imposes a TSG101/ISG15 Checkpoint at the Golgi for Glycoprotein Trafficking during Influenza Virus Infection
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CELL HOST & MICROBE (2013)
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ISG15 Deregulates Autophagy in Genotoxin-treated Ataxia Telangiectasia Cells
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Activation of Double-stranded RNA-activated Protein Kinase (PKR) by Interferon-stimulated Gene 15 (ISG15) Modification Down-regulates Protein Translation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
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ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells
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Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15
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Up-regulation of interferon-stimulated gene15 and its conjugates by tumor necrosis factor-α via type I interferon-dependent and -independent pathways
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Mycobacterial Disease and Impaired IFN-γ Immunity in Humans with Inherited ISG15 Deficiency
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Increased cerebral protein ISGylation after focal ischemia is neuroprotective
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JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2011)
Mechanism of Inhibition of Retrovirus Release from Cells by Interferon-Induced Gene ISG15
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PLOS PATHOGENS (2011)
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CELL (2010)
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy
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EMBO JOURNAL (2010)
The Interferon-Induced Gene ISG15 Blocks Retrovirus Release from Cells Late in the Budding Process
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JOURNAL OF VIROLOGY (2010)
Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification
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The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15
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ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells
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Telomere length regulates ISG15 expression in human cells
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AGING-US (2009)
Expression, regulation and function of the ISGylation system in prostate cancer
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ONCOGENE (2009)
ISG15 expression in response to double-stranded RNA or LPS in cultured Fetal Bovine Lung (FBL) cells
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Nitrosylation of ISG15 prevents the disulfide bond-mediated dimerization of ISG15 and contributes to effective ISGylation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
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MOLECULAR CANCER THERAPEUTICS (2008)
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ISG15 inhibit Ebola VP40VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity
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Vaccinia virus E3 protein prevents the antiviral action of ISG15
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NATURE REVIEWS IMMUNOLOGY (2008)
Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses
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CELL HOST & MICROBE (2007)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP
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GENES & DEVELOPMENT (2007)
IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses
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ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus
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MOLECULAR AND CELLULAR BIOLOGY (2005)
Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia
I Pitha-Rowe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
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CELL (2003)
IRF3 mediates a TLR3/TLR4-specific antiviral gene program
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IMMUNITY (2002)
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BT Hummer et al.
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Novel NEMO/IκB kinase and NF-κB target genes at the pre-B to immature B cell transition
J Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein
WM Yuan et al.
EMBO JOURNAL (2001)
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