期刊
JOURNAL OF CELL SCIENCE
卷 130, 期 15, 页码 2447-2457出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.196154
关键词
Spectraplakin; F-actin; Microtubule; Intermediate filament; Cytoskeletal coordination; Cell-matrix adhesion; Cell-cell junction
类别
资金
- National Institutes of Health [R01 AR063630-01]
- American Cancer Society [124933-RSG-13-198-01-DDC]
The different cytoskeletal networks in a cell are responsible for many fundamental cellular processes. Current studies have shown that spectraplakins, cytoskeletal crosslinkers that combine features of both the spectrin and plakin families of crosslinkers, have a critical role in integrating these different cytoskeletal networks. Spectraplakin genes give rise to a variety of isoforms that have distinct functions. Importantly, all spectraplakin isoforms are uniquely able to associate with all three elements of the cytoskeleton, namely, F-actin, microtubules and intermediate filaments. In this Review, we will highlight recent studies that have unraveled their function in a wide range of different processes, from regulating cell adhesion in skin keratinocytes to neuronal cell migration. Taken together, this work has revealed a diverse and indispensable role for orchestrating the function of different cytoskeletal elements in vivo.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据