期刊
JOURNAL OF CELL SCIENCE
卷 130, 期 14, 页码 2243-2250出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.202192
关键词
Mechanotransduction; Nucleus; Nuclear lamina; Nucleoskeleton; Nuclear mechanical response
类别
资金
- Max-Planck-Gesellschaft (Max Planck Society)
- Max Planck Forderstiftung
- Deutsche Forschungsgemeinschaft [SFB 829]
- Whitaker International Fellows and Scholars Program
- European Union's Horizon research and innovation programme under the Marie Sklodowska-Curie Actions [748004 - MiMEtiC]
Cells are constantly subjected to a spectrum of mechanical cues, such as shear stress, compression, differential tissue rigidity and strain, to which they adapt by engaging mechanisms of mechanotransduction. While the central role of cell adhesion receptors in this process is established, it has only recently been appreciated that mechanical cues reach far beyond the plasma membrane and the cytoskeleton, and are directly transmitted to the nucleus. Furthermore, changes in the mechanical properties of the perinuclear cytoskeleton, nuclear lamina and chromatin are critical for cellular responses and adaptation to external mechanical cues. In that respect, dynamic changes in the nuclear lamina and the surrounding cytoskeleton modify mechanical properties of the nucleus, thereby protecting genetic material from damage. The importance of this mechanism is highlighted by debilitating genetic diseases, termed laminopathies, that result from impaired mechanoresistance of the nuclear lamina. What has been less evident, and represents one of the exciting emerging concepts, is that chromatin itself is an active rheological element of the nucleus, which undergoes dynamic changes upon application of force, thereby facilitating cellular adaption to differential force environments. This Review aims to highlight these emerging concepts by discussing the latest literature in this area and by proposing an integrative model of cytoskeletal and chromatin-mediated responses to mechanical stress.
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