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DNA damage-induced immune response: Micronuclei provide key platform

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JOURNAL OF CELL BIOLOGY
卷 216, 期 10, 页码 2999-3001

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ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201708069

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资金

  1. Laboratory for Molecular Infection Medicine Sweden
  2. Vetenskapsradet [2015-02857, 2016-00890]
  3. Swedish Research Council [2016-00890, 2015-02857] Funding Source: Swedish Research Council

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DNA damage-induced activation of the cytoplasmic DNA sensor cGAS influences the outcome of infections, autoinflammation, and cancer. Recent studies by Harding et al. (2017. Nature. http://dx.doi.org/10.1038/nature23470), Mackenzie et al. (2017. Nature. http://dx.doi.org/10.1038/nature23449), and Bartsch et al. (2017. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddx283) demonstrate a role for micronuclei formation in DNA damage-induced immune activation.

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