期刊
DALTON TRANSACTIONS
卷 44, 期 9, 页码 3945-3948出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4dt03897e
关键词
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资金
- NCI [R01CA093375, R01 CA064475]
- UPCI CCSG [P30CA047904]
- National Science Foundation [CHE-0741793]
Copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry has inherent challenges for copper-labeled radio-pharmaceuticals. An azide-modified phosphonate-based cross-bridged macrocyclic chelator was synthesized for click chemistry conjugation with azide-modified Y3-TATE (a somatostatin analogue) on resin, without the need for protecting the chelator. The Cu-64-labeled bioconjugate shows favourable in vitro and in vivo behaviour.
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