期刊
JOURNAL OF EXERCISE REHABILITATION
卷 16, 期 1, 页码 2-9出版社
KOREAN SOC EXERCISE REHABILITATION
DOI: 10.12965/jer.2040016.008
关键词
Neuroinflammation; Cytokines; Depression; Affective disorders
资金
- National Research Foundation of the Korean government [NRF-2016M3C7A1905384]
- National Research Foundation of Korea [2016M3C7A1905384] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Accumulating evidence suggests that neuroinflammation plays an important role in etiology of psychiatric disorders. Neuronflammabon involves a combination of psychological, neuroendocrine, and nervous systems resulting in changes of neurotransmitter metabolism, dysregulation of the hypothalamus-pituitary-adrenal axis, pathologic microglial cell activation, impaired neuroplasticity, and structural and functional brain changes affecting cognition and emotional behavior. Inflammatory cytokines have been postulated to be the possible link and culprit in the disruption of these systems. The outcome of any type of dysregulation of the immune system in the brain might lead to occurrence of depression, anxiety. This review focuses on the possible impact of dysregulated cytokine networks which may cause pathogenesis of affective disorders such as depression and anxiety.
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