期刊
DALTON TRANSACTIONS
卷 49, 期 8, 页码 2412-2416出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9dt04819g
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资金
- Beneficentia Stiftung (Vaduz, Liechtenstein)
- Italian Association for Cancer Research (AIRC) - Ente Cassa di Risparmio di Firenze (ECRF) [19650]
- AIRC foundation
- University of Pisa
The interactions between the cytotoxic paddlewheel dirhodium complex [Rh-2(mu-O2CCH3)(4)] and the model protein bovine pancreatic ribonuclease (RNase A) were investigated by high-resolution mass spectrometry and X-ray crystallography. The results indicate that [Rh-2(mu-O2CCH3)(4)] extensively reacts with RNase A. The metal compound binds the protein via coordination of the imidazole ring of a His side chain to one of its axial sites, while the dirhodium center and the acetato ligands remain unmodified. Data provide valuable information for the design of artificial dirhodium-containing metalloenzymes.
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