期刊
FOOD & FUNCTION
卷 11, 期 2, 页码 1230-1234出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9fo02933h
关键词
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资金
- China Scholarship Council (CSC)
- European Union
- European Regional Development Fund
- Northern Netherlands Provinces (Samenwerkingsverband Noord-Nederland)
- KOERS NOORD
Lactic acid bacteria (LAB) are recognized for support of host gut homeostasis but the precise mechanisms remain to be identified. LABs interact with Toll-like receptors (TLRs) which might stimulate barrier function of gut epithelial cells. We previously identified six TLR2-signalling LAB strains. As TLR2 is involved in barrier-function enhancement in gut-epithelium, the epithelial barrier-protective effect of these TLR2-signalling strains was studied by using T84 human colorectal cancer cell monolayer as an in vitro gut epithelial barrier model. The protein kinase C (PKC) dependent barrier disruptor A23187 and mitogen-activated protein kinase dependent barrier stressor deoxynivalenol were tested to determine which pathways LAB influenced. We found that exclusively the PKC dependent disruption was prevented by the selected TLR2-signalling LAB strains. This study suggests that TLR2 is a pivotal epithelial barrier modulator, and provides novel insight in the molecular mechanisms by which LAB contribute to intestinal health.
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