期刊
THERANOSTICS
卷 10, 期 7, 页码 3099-3117出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.42998
关键词
tumor immunology; characterization and quantification of immunoregulatory cells; nanoparticles; drug delivery; combination therapy
资金
- Carolina Center for Cancer Nanotechnology Excellence (NIH) [CA198999]
- Talents Cultivation Program of Jilin University
Recent advances in the field of immunotherapy have profoundly opened up the potential for improved cancer therapy and reduced side effects. However, the tumor microenvironment (TME) is highly immunosuppressive, therefore, clinical outcomes of currently available cancer immunotherapy are still poor. Recently, nanomaterial-based strategies have been developed to modulate the TME for robust immunotherapeutic responses. In this review, the immunoregulatory cell types (cells relating to the regulation of immune responses) inside the TME in terms of stimulatory and suppressive roles are described, and the technologies used to identify and quantify these cells are provided. In addition, recent examples of nanomaterial-based cancer immunotherapy are discussed, with particular emphasis on those designed to overcome barriers caused by the complexity and diversity of TME.
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