期刊
NANOSCALE
卷 12, 期 8, 页码 5139-5150出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9nr10039c
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资金
- National Natural Science Foundation of China [21671135]
- Shanghai Rising-Star Program [17QA1402600]
- Shanghai Talent Development Fund [2018082]
- Shanghai Sailing Program [19YF1436200]
- International Joint Laboratory on Resource Chemistry (IJLRC)
The use of smart theranostic agents in multimodal imaging and treatment is a promising strategy to overcome the limitations of single mode diagnosis and treatment, and can greatly improve the diagnosis and effects of treatment. In this study, a gold@manganese dioxide (Au@MnO2) core-shell nanostructure was designed as a glutathione (GSH)-triggered smart theranostic agent for photoacoustic and magnetic resonance (MR) dual-imaging-guided photothermal-enhanced chemodynamic therapy. Both in vitro and in vivo experiments demonstrated not only that the photoacoustic and MR imaging function of Au@MnO2 could be activated by a high endogenous GSH concentration, but also that after being triggered by the endogenous GSH, Au@MnO2 had an excellent synergistic treatment effect in photothermal-enhanced chemodynamic therapy under the guidance of photoacoustic and MR imaging. This study demonstrated that the use of GSH-triggered Au@MnO2 in photoacoustic and MR dual-imaging-guided photothermal-enhanced chemodynamic therapy is a smart theranostic nanoplatform for the accurate diagnosis and efficient treatment of cancer.
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