期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 33, 期 1, 页码 63-69出版社
WILEY
DOI: 10.1002/jbmr.3287
关键词
VERTEBRAL FRACTURES; DIABETES; BONE QCT; VOLUMETRIC BMD; FRACTURE RISK ASSESSMENT
资金
- National Institutes of Health
- National Institute on Aging (NIA)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
- National Center for Advancing Translational Sciences (NCATS)
- NIH Roadmap for Medical Research [U01 AR45580, U01 AR45614, U01 AR45632, U01AR45647, U01 AR45654, U01 AR45583, U01 AG18197, U01, AG027810, UL1 TR000128]
- American Diabetes Association [1-04-JF-46]
- VA Clinical Science Research and Development Career Development Award [5IK2CX000549-05]
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR002369] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [U01AR066160, P30AR066262] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [U01AG027810] Funding Source: NIH RePORTER
Type 2 diabetes (T2DM) is associated with a significant increase in risk of nonvertebral fractures, but information on risk of vertebral fractures (VFs) in subjects with T2DM, particularly among men, is lacking. Furthermore, it is not known whether spine bone mineral density (BMD) can predict the risk of VF in T2DM. We sought to examine the effect of diabetes status on prevalent and incident vertebral fracture, and to estimate the effect of lumbar spine BMD (areal and volumetric) as a risk factor for prevalent and incident morphometric vertebral fracture in T2DM (n=875) and nondiabetic men (n=4679). We used data from the Osteoporotic Fractures in Men (MrOS) Study, which enrolled men aged 65 years. Lumbar spine areal BMD (aBMD) was measured with dual-energy X-ray absorptiometry (DXA), and volumetric BMD (vBMD) by quantitative computed tomography (QCT). Prevalence (7.0% versus 7.7%) and incidence (4.4% versus 4.5%) of VFs were not higher in T2DM versus nondiabetic men. The risk of prevalent (OR, 1.05; 95% CI, 0.78 to 1.40) or incident vertebral-fracture (OR, 1.28; 95% CI, 0.81 to 2.00) was not higher in T2DM versus nondiabetic men in models adjusted for age, clinic site, race, BMI, and aBMD. Higher spine aBMD was associated with lower risk of prevalent VF in T2DM (OR, 0.55; 95% CI, 0.48 to 0.63) and nondiabetic men (OR, 0.66; 95% CI, 0.5 to 0.88) (p for interaction=0.24) and of incident VF in T2DM (OR, 0.50; 95% CI, 0.41 to 0.60) and nondiabetic men (OR, 0.54; 95% CI, 0.33 to 0.88) (p for interaction=0.77). Results were similar for vBMD. In conclusion, T2DM was not associated with higher prevalent or incident VF in older men, even after adjustment for BMI and BMD. Higher spine aBMD and vBMD are associated with lower prevalence and incidence of VF in T2DM as well as nondiabetic men. (c) 2017 American Society for Bone and Mineral Research.
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