期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 33, 期 2, 页码 356-361出版社
WILEY
DOI: 10.1002/jbmr.3298
关键词
OSTEOPOROSIS; DNA METHYLATION; EPIGENETIC; AGING; BIOMARKER
资金
- German Ministry of Education and Research (OBELICS) [01KU1402A, 01KU1402B]
- German Research Foundation [WA1706/8-1]
Osteoporosis is an age-related metabolic bone disease. Hence, osteoporotic patients might suffer from molecular features of accelerated aging, which is generally reflected by specific age-associated DNA methylation (DNAm) changes. In this study, we analyzed genomewide DNAm profiles of peripheral blood from patients with manifest primary osteoporosis and non-osteoporotic controls. Statistical analysis did not reveal any individual CG dinucleotides (CpG sites) with significant aberrant DNAm in osteoporosis. Subsequently, we analyzed if age-associated DNAm patterns are increased in primary osteoporosis (OP). Using three independent age-predictors we did not find any evidence for accelerated epigenetic age in blood of osteoporotic patients. Taken together, osteoporosis is not reflected by characteristic DNAm patterns of peripheral blood that might be used as biomarker for the disease. The prevalence of osteoporosis is age-associatedbut it is not associated with premature epigenetic aging in peripheral blood. (c) 2017 American Society for Bone and Mineral Research.
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