期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 32, 期 7, 页码 1559-1567出版社
WILEY
DOI: 10.1002/jbmr.3125
关键词
BIOCHEMICAL MARKERS OF BONE TURNOVER; OSTEOPOROSIS; GENERAL POPULATION STUDIES
资金
- National Institutes of Health (NIH): National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
- National Institute on Aging (NIA)
- National Center for Advancing Translational Sciences (NCATS)
- NIH Roadmap for Medical Research [U01AR45580, U01AR45614, U01AR45632, U01AR45647, U01AR45654, U01AR45583, U01AG18197, U01AG027810, UL1RR024140]
- National Institutes of Health (NIH) NIGMS grant [P41 GM103493]
- DOE [DE-AC05-76RL0 1830]
- NIH/NCATS [UL1TR000128]
- Common Fund of the Office of the Director of the NIH
- NCI
- NHGRI
- NHLBI
- NIDA
- NIMH
- NINDS
- [P50 AR063043]
- [K01 AR062655]
Serum proteomics analysis may lead to the discovery of novel osteoporosis biomarkers. The Osteoporotic Fractures in Men (MrOS) study comprises men >= 65 years old in the US who have had repeated BMD measures and have been followed for incident fracture. High-throughput quantitative proteomic analysis was performed on baseline fasting serum samples from non-Hispanic white men using a multidimensional approach coupling liquid chromatography, ion-mobility separation, and mass spectrometry (LC-IMS-MS). We followed the participants for a mean of 4.6 years for changes in femoral neck bone mineral density (BMD) and for incident hip fracture. Change in BMD was determined from mixed effects regression models taking age and weight into account. Participants were categorized into three groups: BMD maintenance (no decline; estimated change >= 0 g/cm(2), n = 453); expected loss (estimated change 0 to 1 SD below the estimated mean change, -0.034 g/cm(2) for femoral neck, n =1184); and accelerated loss (estimated change >= 1 SD below mean change, n = 237). Differential abundance values of 3946 peptides were summarized by meta-analysis to determine differential abundance of each of 339 corresponding proteins for accelerated BMD loss versus maintenance. Using this meta-analytic standardized fold change at cutoffs of >= 1.1 or <= 0.9 (p< 0.10), 20 proteins were associated with accelerated BMD loss. Associations of those 20 proteins with incident hip fracture were tested using Cox proportional hazards models with age and BMI adjustment in 2473 men. Five proteins were associated with incident hip fracture (HR between 1.29 and 1.41 per SD increase in estimated protein abundance). Some proteins have been previously associated with fracture risk (eg, CD14 and SHBG), whereas others have roles in cellular senescence and aging (B2MG and TIMP1) and complement activation and innate immunity (CO7, CO9, CFAD). These findings may inform development of biomarkers for future research in bone biology and fracture prediction. (C) 2017 American Society for Bone and Mineral Research.
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