4.7 Article

Biomineralized nanoparticles enable an enzyme-assisted DNA signal amplification in living cells

期刊

CHEMICAL COMMUNICATIONS
卷 56, 期 19, 页码 2901-2904

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc09503a

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资金

  1. National Key R&D Programof China [2019YFA0210103]
  2. National Natural Science Foundation of China [21890744, 21705038, 21605038]
  3. Science and Technology Project of Hunan Province [2016RS2009, 2016WK2002]
  4. Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Hunan Normal University), Ministry of Education

向作者/读者索取更多资源

The enzymatic-assisted signal amplification of DNA sensors is rarely applied in living cells due to the difficulties in protein delivery. In this study, we have proposed a biomineralization-based DNA nanoprobe to transport nucleases and DNA sensors for enzyme-assisted imaging of microRNA in living cells.

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