期刊
CHEMICAL SCIENCE
卷 11, 期 9, 页码 2414-2419出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9sc05894j
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资金
- National Science Foundation of China [21722204, 21971148]
- Fok Ying Tung Education Foundation [151035]
- Youth Interdiscipline Innovative Research Group of Shandong University [2020QNQT009]
A cross-dehydrogenative coupling strategy for enantioselective access to acyclic CF3-substituted all-carbon quaternary stereocenters has been established. By using catalytic DDQ with MnO2 as an inexpensive terminal oxidant, asymmetric cross coupling of racemic delta-CF3-substituted phenols with indoles proceeded smoothly, providing CF3-bearing all-carbon quaternary stereocenters with excellent chemo- and enantioselectivities. The generality of the strategy is further demonstrated by efficient construction of all-carbon quaternary stereocenters bearing other polyfluoroalkyl and perfluoroalkyl groups such as CF2Cl, C2F5, and C3F7.
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