期刊
JOURNAL OF BIOSCIENCES
卷 42, 期 1, 页码 155-159出版社
INDIAN ACAD SCIENCES
DOI: 10.1007/s12038-017-9666-9
关键词
Cell cycle regulation; SET1 family; transcription; WRAD
类别
资金
- Council of Scientific and Industrial Research (CSIR), India
- DBT [BT/BR15453/ BRB/10/927/2011]
- DST [SB/SO/BB-069/2013]
- CDFD core
WD repeat containing protein 5 (WDR5), Retinoblastoma Binding Protein 5 (RbBP5), Absent-Small-Homeotic-2-Like protein (ASH2L), and Dumpy-30 (Dpy30) have been reported to be the integral and shared components of all the SET1 family of histone 3 lysine 4 histone methyltransferase (HMT) complexes. Collectively called the WRAD complex, these proteins are pivotal to the HMT activity of the SET1 complexes. Recent reports highlight the novel non-canonical functions of WRAD in cellular processes other than its well-studied role in histone methylation and gene expression. In this review, we examine the diversity in emerging transcription-independent functions of WRAD.
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