期刊
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY
卷 48, 期 1, 页码 30-35出版社
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnmt.119.231118
关键词
MTV; TLG; Hodgkin lymphoma; F-18-FDG PET/CT; VOI; SUV
资金
- FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [2009/54065-0, 2018/00654-4]
- CNPq (National Council of Research) [311841/2018-0, 305110/2018-7]
- Nuclear and Energy Research Institute (IPEN-CNEN), Sao Paulo, Brazil [01342000458/2017-15]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [09/54065-0] Funding Source: FAPESP
Quantification of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) can be time-consuming. We evaluated the performance of an automatic multifocal segmentation (MFS) method of quantification in patients with different stages of Hodgkin lymphoma, using the multiple VOI (MV) method as reference. Methods: This prospective bicentric study included 50 patients with Hodgkin lymphoma who underwent staging F-18-FGD PET/CT. The examinations were centrally reviewed and processed with commercial MFS software to obtain MTV and TLG using 2 fixed relative thresholds (40% and 20% of SUV max ) for each lesion. All PET/CT scans were processed using the MV and MFS methods. Interclass correlation coefficients and Bland-Altman plots were used for statistical analysis. Repeated calculations of MW and TLG values by 2 observers with different degrees of PET/CT imaging experience were used to ascertain interobserver agreement on the MFS method. Results: The means and SDs obtained for the MW with MV and MFS were, respectively, 736 +/- 856 mL and 660 +/- 699 mL for the 20% threshold and 313 +/- 359 mL and 372 +/- 434 mL for the 40% threshold. The time spent calculating the MW was much shorter with the MFS method than with the MV method (median time, 11.6 min [range, 1-30 min] and 64.4 min [range, 1-240 min], respectively), especially in patients with advanced disease. Time spent was similar in patients with localized disease. There were no statistical differences between the MFS values obtained by the 2 different observers. Conclusion: MTV and TLG calculations using MFS are reproducible, generate similar results to those obtained with MV, and are much less timing-consuming. Main differences between the 2 methods were related to difficulties in avoiding overlay of VOIs in the MV technique. MV and MFS perform equally well in patients with a small number of lesions.
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