期刊
JOURNAL OF BIOPHOTONICS
卷 11, 期 5, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201700199
关键词
bioimaging; biomarkers; brain tissue; europium nitrate; fluorescence; integrated photoluminescence ratio; L-lactic acid; plasma; serum
资金
- Engineering and Physical Sciences Research Council [EP/M015165/1]
- EPSRC [EP/M015165/1]
- EPSRC-IAA
- Biotechnology and Biological Sciences Research Council [BB/M013111/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/M015165/1] Funding Source: researchfish
- BBSRC [BB/M013111/1] Funding Source: UKRI
- EPSRC [EP/M015165/1] Funding Source: UKRI
Instant measurement of elevated biomarkers such as lactic acid offers the most promising approaches for early treatment and prevention of many critical diseases including cardiac arrest, stroke, septic shock, trauma, liver dysfunction, as well as for monitoring lactic acid level during intense exercise. In the present study, a unique dependence of visible photoluminescence of Eu3+ ions resulting from D-5(0) to F-7(J(J = 0,1,2,3,4)) transitions, which can be exploited for rapid detection of biomarkers, both in vitro and ex vivo, has been reported. It is observed that the integrated intensity ratio of photoluminescence signals dominating at 591 and 616 nm originating from D-5(0) to F-7(2) and D-5(0) to F-7(1) transitions in Eu3+ ions can be used as a biosensing and bioimaging tool for detection of biomarkers released at disease states. The Eu3+ integrated photoluminescence intensity ratio approach reported herein for optical detection of lactates in blood serum, plasma and confocal imaging of brain tissues has very high potential for exploitation of this technique in both in vitro monitoring and in vivo bioimaging applications for the detection of biomarkers in various diseases states.
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