4.6 Article

Alzheimer mouse brain tissue measured by time resolved fluorescence spectroscopy using single- and multi-photon excitation of label free native molecules

期刊

JOURNAL OF BIOPHOTONICS
卷 11, 期 1, 页码 -

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201600318

关键词

Alzheimer disease; time resolved fluorescence spectroscopy; label free molecule; multiphoton excitation; brain optics

资金

  1. Corning
  2. ARO
  3. NIH [5SC1HD068129]
  4. National Center for Research Resources [2G12RR003060-26 A1]

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Time resolved spectroscopic measurements with single-photon and multi-photon excitation of native molecules were performed ex vivo on brain tissues from an Alzheimer's disease (AD) and a wild type (WT) mouse model using a streak camera. The fluorescence decay times of native NADH and FAD show a longer relaxation time in AD than in WT tissue, suggesting less nonradiative processes in AD. The longer emission time of AD may be attributed to the coupling of the key native building block molecules to the amyloid-tau and/or to the caging of the native fluorophores by the deposition of amyloid-beta or tau plaques and neurofibrillary tangles that affect the local non-radiative interactions.

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