期刊
CHINESE JOURNAL OF NATURAL MEDICINES
卷 18, 期 2, 页码 81-89出版社
CHINESE JOURNAL NATURAL MEDICINES
DOI: 10.1016/S1875-5364(20)30009-1
关键词
Liparis nervosa; Pyrrolizidine alkaloids; Nervosine VII; Autophagy; Apoptosis; HCT116 cells
资金
- National Natural Science Foundation of China [81402803]
Nervosine VII is one of the known saturated pyrrolizidine alkaloids isolated from the plant of Liparis nervosa. This is first study to investigate the antitumor activity of nervosine VII in vitro, and the results indicated that nervosine VII induced autophagy and apoptosis in HCT116 human colorectal cancer cells. Mechanistic studies showed that nervosine VII-induced apoptosis was associated with the intrinsic pathway by the activation of caspase-9, -3 and -7. Autophagy induced by nervosine VII was characteristic with the regulation of autophagic markers including the increase of LC3-II and beclin 1 proteins, and the decrease of p62 protein. Nervosine VII simultaneously induced autophagy and apoptosis by activated MAPKs signaling pathway including JNK, ERK1/2 and p38, suppressing the p53 signaling pathway.
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