期刊
JOURNAL OF BIOPHOTONICS
卷 10, 期 12, 页码 1676-1682出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201600241
关键词
Chemotherapy; doxorubicin; metastatic lymph nodes; photothermal treatment; thermosensitive agents
资金
- JSPS KAKENHI [16H04273, 26293425, 16 K15816, 26242051, 24650286]
- Grants-in-Aid for Scientific Research [16K15816, 16H04273, 17H02111] Funding Source: KAKEN
Tumor metastasis to lymph nodes is an important contributory factor for cancer-related deaths despite recent developments in cancer therapy. In this study, we demonstrate that tumor in the proper axillary lymph node (PALN) of the mouse can be treated by the application of external laser light to trigger the unloading of doxorubicin (DOX) encapsulated in thermosensitive liposomes (TSLs) administered together with gold nanorods (GNRs). GNRs + DOX-TSLs were injected into a mouse lymph node containing cancer cells (malignant fibrous histiocytoma-like cells) and intranodal DOX release was activated using near-infrared (NIR) laser irradiation. The temperature changes arising from the laser-irradiated GNRs triggered the release of DOX from the TSLs. A greater degree of inhibition of tumor growth was found in the co-therapy group compared to the other groups. The treatment effect was achieved by a combination of chemotherapy and NIR-activated hyperthermia. In vivo bioluminescence imaging and histological analysis confirmed tumor necrosis in response to combined treatment. This work presents a theranostic approach with excellent treatment results that has the potential to be developed into an alternative to surgery for the treatment of breast cancer metastasis. [GRAPHICS] .
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据